Choroid Plexus Cysts are a well-known ultrasound aneuploidy marker and are easily detectable at second-trimester ultrasound examination , showing an incidence in euploid fetus close to 1 percent and a positive predictive value of 1 to 6 percent . The association with other fetal anomalities , their bilateralism , a diameter bigger than 10 mm and their persistence after 22 to 24 weeks have been classical indication for cytogenetic fetal study. A prospective study of advanced age women found that if fetal CPCs appear to be isolated , genetic amniocentesis is not mandatory and additional risk factors such as advanced maternal age should be the main indication for fetal karyotyping .

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