Absolute:
1.Thomboembolic disease;
2.Acute and chronic disease of liver;
3.Cancer of breast or genitals;
4.Pregnancy known or suspected;
5.Focal migraine.

Relative:
1.Hypertension;
2.Valvular heart disease;
3.Epilepsy;
4.Smokers over 35 years;
5.Nursing mothers;
6.Sickle-cell anemia , thalassemia;
7.Asthma;
8.Allergic disorders;
9.Herpes gestationalies;
10.Porphyria;
11.Pruritus of pregnancy;
12.Varicose veins;
13.Obesity;
14.Elective surgery;
15.Diabetes;
16.Crohn’s disease.